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Jan Bosch is a research center director, professor, consultant and angel investor in startups. You can contact him at jan@janbosch.com.

Opinion

From copilot to colleague: the rise of agentic AI

20 April 2026
Reading time: 5 minutes

The question for most organizations isn’t whether to engage with agentic AI but how quickly and how deliberately.

Since the introduction of ChatGPT in 2022, artificial intelligence in the enterprise has been fundamentally assistive. AI systems have answered questions, generated suggestions, summarized documents and flagged anomalies. Humans have long remained firmly in control of every consequential action. The AI provided input; the person made the decision and pressed the button. This was a useful first step, but it left most of the coordination cost, the handoffs, the chasing, the manual reconciliation, exactly where it had always been: with people.

That model is now changing. A new generation of AI systems is emerging that doesn’t wait for instructions. These systems are given a goal, after which they figure out the steps required to achieve it, execute those steps across multiple tools and systems, adapt when something goes wrong and report back when the task is done. They are, in a meaningful sense, autonomous software colleagues rather than sophisticated autocomplete. The industry has started calling them agents, and the shift from copilot to agent is more significant than it might initially appear.

The difference isn’t merely one of capability; it’s a difference in the unit of work. Whereas a copilot operates at the level of the individual interaction, an agent operates at the level of the workflow. This matters because in most organizations, the bottleneck isn’t the individual task but the coordination between tasks. Getting a claim processed, an expense report approved or a sales lead qualified requires not one action but a sequence of them, spread across multiple systems, involving judgment at several points along the way. When AI can own that entire sequence rather than just assist with individual steps, the productivity implications are of a different order entirely.

Several companies illustrate what this looks like in practice. Thoughtful AI, a healthcare revenue cycle management outfit recently merged into Smarter Tech, has deployed a team of specialized autonomous agents across billing workflows. Different agents handle eligibility verification, medical coding, claims submission and denial management. They coordinate across electronic health record systems and payer portals, learning from prior rejections and adjusting their approach over time. The result is that billing staff, previously consumed by high-volume repetitive processing, can redirect their attention to exception handling and strategic improvement. The agents don’t replace judgment; they handle the work that didn’t require judgment but was consuming the time of people who have it.

Ramp, the corporate finance platform, has taken a similar approach to expense management. Its AI finance agent reads company policy documents, audits expenses continuously, flags violations automatically, routes approvals without human intervention and coordinates with procurement systems to verify vendor compliance in advance. What was previously a periodic, manual process with significant lag and inconsistency has become a continuous, policy-driven operation. The finance team is no longer processing transactions; it’s governing a system that processes them.

A structurally similar pattern is visible in supply chain operations at scale. Walmart deployed an autonomous inventory agent to optimize stock placement in real-time across its e-commerce operations. Unlike traditional machine learning models, which surface insights for humans to act on, this agent executes the full workflow: It detects demand signals, generates forecasts, makes inventory decisions and initiates the corresponding actions, without waiting for an analyst to review a dashboard. The outcome in pilot regions was a 22 percent increase in e-commerce sales driven primarily by improvements in product availability.

What connects these examples is an architectural pattern that’s becoming increasingly standard. Rather than deploying a single, general-purpose agent and expecting it to handle everything, leading organizations are building orchestrated systems of specialized agents. Each agent has a narrow, well-defined responsibility. An orchestration layer coordinates how work moves between them and manages escalation when human judgment is genuinely required. This structure mirrors how effective human teams already operate. It also makes the systems more reliable, more auditable and easier to improve incrementally.

The human role in this model is shifting accordingly. Microsoft has coined the term “agent boss” to describe what the new role looks like: not someone who executes tasks, but someone who defines goals, configures agents, monitors outcomes and intervenes when the system encounters something it can’t resolve. This is a meaningful change in how knowledge work is organized, and organizations that understand it early will have a significant advantage in structuring their teams and processes.

It would be misleading, however, to present this as purely straightforward. The practical challenges of deploying agentic AI at scale are substantial and frequently underestimated. MIT research on an agent designed to detect adverse events in cancer patient records found that approximately 80 percent of the implementation effort was consumed not by AI engineering but by data preparation, stakeholder alignment, governance design and system integration. The agent itself was the easier part; making the surrounding organizational and technical environment ready was the hard part.

The gap between pilot and production is wide

This points to a broader truth about where agentic AI is in its adoption curve. Despite enormous enthusiasm, a recent Deloitte survey found that only 11 percent of organizations have agentic AI systems actively running in production. The gap between pilot and production is wide and primarily concerning data infrastructure, governance and organizational readiness rather than model capability. The companies that will gain the most from this shift are those that treat agent deployment as an organizational and engineering discipline, not just a technology experiment.

The strategic implications for software-intensive companies are significant. Agentic AI creates a new kind of competitive asymmetry. Companies that successfully deploy autonomous agents in their core workflows don’t just become more efficient; they develop organizational capabilities that are difficult to replicate quickly. Agent systems require investment in data architecture, workflow mapping, governance frameworks and operational monitoring. Those investments compound. The organization that has deployed agents across its revenue cycle, supply chain and finance operations simultaneously develops deep operational expertise in running agentic systems, which is itself a form of competitive advantage.

The analogy to earlier waves of enterprise software is instructive. When ERP systems were adopted at scale in the 1990s and 2000s, the companies that implemented them most effectively didn’t merely automate existing processes. They redesigned their operations around the capabilities of the new systems. The same opportunity exists now, but the scope of potential redesign is considerably larger. Where ERP systematized data management, agentic AI systematizes decision-making across entire workflows.

The transition from AI as an assistant to AI as an autonomous colleague is not a distant prospect. It’s happening now, unevenly and imperfectly, but at a meaningful scale across healthcare, finance, retail and logistics. The question for most organizations isn’t whether to engage with this shift but how quickly and how deliberately. As Andrew Ng has observed, “Just as electricity transformed almost every industry 100 years ago, AI will transform industries in the coming years.” Agentic AI is where that transformation becomes concrete.

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